The SZABIST Head Office is responsible for the Board of Governors and all estate matters. The Head Office sponsors a number of SZABIST projects, which are currently in the final stages of approval and development. The Head Office handles the agenda items for the Board of Governors meetings and disseminates information on SZABIST University.
| Madam Bakhtwar Bhutto Zardari | Chairperson |
| Dr. Azra Fazal Pechuho | Co-Chairperson & Chancellor |
| Mr. Aftab Shahban Mirani | Vice-Chairman |
| Ms. Aseefa Bhutto Zardari | Member |
| Mr. Abdul Razak Soomro | Member |
| Mr. Khurshed Ahmed Junejo | Member |
| Dr. Nafisa Shah | Member |
| Dr. Talib Hussain Lashari | Member |
| Mr. Zahoor Hussain Shujra | Member |
| Mr. Ali Mandviwalla | Member |
| Mr. Muhammad Qasim Soomro | Member |
| Mr. Syed Tariq Mustafa | Member |
| Mr. Muhammad Ahmed Shah | Member |
| Mr. Noor Ahmed Samoo | Secretary Universities & Boards Department Govt. of Sindh |
| Dr. Ali Farhan |
Member On Behalf of Sindh HEC |
| Ms. Shahnaz Wazir Ali | President SZABIST/ Ex-officio Member |
| Dr. M. Suleman Shaikh | Advisor to Chairperson/Co-Chairperson Ex-Officio Member |
| Mr. Sohail Akber Shah | Secretary Board of Governors |
